It would appear that the genetics for bowel cancer are more complex then previously thought. In this study 1443 colorectal cancers in two US nationwide prospective cohort studies were studied. Frequencies of molecular features were examined along bowel subsites (rectum, rectosigmoid junction, sigmoid, descending colon, splenic flexure, transverse colon, hepatic flexure, ascending colon and caecum). The frequencies of CIMP-high, MSI-high and BRAF mutations gradually increased from the rectum (<2.3%) to ascending colon (36–40%), followed by falls in the caecum (12–22%). Caecal cancers exhibited the highest frequency of KRAS mutations (52% vs 27–35% in other sites; p<0.0001).
Headline: Molecular assessment of patients with colorectal cancer may have impact on future therapeutic strategies
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